Oral bioavailability in sheep of albendazole from a suspension and from a solution containing hydroxypropyl-β-cyclodextrin
作者： Brigitte Evrard , Patrice Chiap , Pascal DeTullio , F Ghalmi , Géraldine Piel
DOI: 10.1016/S0168-3659(02)00270-5
关键词:
摘要: Albendazole (ABZ) is a benzimidazole derivative with broad spectrum of activity against human and animal helminthe parasites. ABZ has very poor aqueous solubility. This study shows that hydroxypropyl-beta-cyclodextrin (HP-beta-CD) able to form inclusion complexes increase its A synergistic effect exists between HP-beta-CD citric acid. The combination (200 mM) acid (50 allows dissolution more than 1.5 mg per ml. aim this the in vivo evaluation sheep solution complex comparison suspension same drug. significant (P proportional, variant )) 37% higher obtained suspension. Likewise peak plasma concentration (C(max)) twice while time reach C(max) (T(max)) reduced.
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