Enhanced Water-Solubility of Albendazole by Hydroxy-Propyl-β-Cyclodextrin Complexation
作者： V. L. Bassani , D. Krieger , D. Duchene , D. Wouessidjewe
DOI: 10.1007/978-94-011-5448-2_70
关键词:
摘要: The inclusion complexation of methyl (5-(propylthio)-1H-benzimidazol-2-yl) carbamate, albendazole (ABZ) with 2-hydroxypropyl-β-cyclodextrin (HPβCD) in water was investigated a view to improving the low aqueous solubility drug. combination and HPβCD molar ratio 1/10 resulted significant increase aqeous solublity drug, up 3500 times. Albendazole/HPβCD complexes could be recommended as parenterally administered formulation because its good properties safety cyclodextrin used.
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