Formulation of poorly water-soluble drugs via coacervation – A pilot study using febantel

摘要: Abstract In this study, febantel was dissolved under increased temperature in a nonionic surfactant Lutrol L44® and subsequently mixed into an aqueous maltodextrin solution. After 8 h static conditions, coacervation or phase separation took place. 1H NMR spectra HPLC analysis showed that the upper contained mainly all febantel, while no detected lower phase. Fluorescent microscopy is distributed Coacervation proved to be promising formulation technology for certain poorly water-soluble drugs, such as febantel. The coacervate increase vitro dissolution kinetics, compared Rintal® granules. These results were confirmed vivo study performed on dogs. Febantel fenbendazole significant plasma concentration Further studies have transform coacervates solid dosage form prove broad applicability other soluble drugs.