Neurocognitive profile and its association with psychopathology in first-degree relatives of patients with schizophrenia. A case-control study

摘要: Abstract Background People with schizophrenia show a broad range of neurocognitive deficits, which are considered as core features the disorder and thought to be partly heritable. Similar albeit at lesser degree, have been also found in their healthy biological relatives. These if better characterized, might represent underlying vulnerable traits for psychosis. Methods This case-control study compared functioning adult first-degree relatives patients (SCZ-RELs) ( n =55) control subjects explored its association negative symptoms. Subjects both group were assessed an extensive test battery (Trail Making test, Phonemic Verbal fluency, Wisconsin Card Sorting Test, Bushke Fuld Stroop n- Back Digit span) set clinical measures (SANS, GAF DAS). Results SCZ-RELs more significantly impaired on executive function tasks (i.e. Test fluency) displayed severe symptoms poorer social than subjects. Significant correlations between group, whereas no significant detected among controls. Discussion Subtle impairments, associated symptoms, shown evident schizophrenia. reflect subtle dysfunction concept formation, flexibility mental shifting, may seen potential phenotypic markers vulnerability raises question prefrontal feature disorder.