Hepatic clearance mechanism of Tc-99m-HIDA and its effect on quantitation of hepatobiliary function: Concise communication.

摘要: Parameters affecting the hepatobiliary clearance of Tc-99m N(2,6-dimethylphenyl carbamoylmethyl) iminodiacetic acid (Tc-HIDA) were evaluated in dogs. Competitive studies, performed with Tc-HIDA after infusion to plasma saturation levels an anion, sodium sulfobromophthalein (BSP), and a cation, oxyphenonium. The results demonstrated that is transported through hepatocytes by carrier-mediated organic-anion pathway. data are consistent alteration elimination kinetics induced elevations serum bilirubin level, it predicted at some increased concentration will dominate distribution independently status. A quantitative description liver function terms regional rate constants require either pharmacokinetic model expressly includes effects bilirubin, development new anionic agents capable displacing endogenous from transport binding sites, or use different mechanism used bilirubin.