Genetic susceptibility to radiation and chemotherapy injury: diagnosis and management

摘要: Over 5% of the cancer patient population may be radiation sensitive due to genetics, and patients greatly overrepresented among with therapy complications. These individuals include not only rare ataxia telangiectasia (AT) homozygotes up three-fold normal sensitivity, but also far more numerous slight radiosensitivity conjectured carriers AT or have another inherited mutagen sensitivity. Procedures eventually used reliably determine tolerance for antineoplastic agents before initiation completion therapy, approach exceed individual patient's irradiated tissue. Such procedures could study cultured cells (e.g., fibroblasts, marrow cells, lymphocytes) in much same way that patients' tumor widely human stem cell assay predict which course radiotherapy chemotherapy should most useful treating a cancer. Studies cytotoxicity assays, serially determined accumulated genetic damage over Southern blot analysis identify DNA repair mutations. studies permit aggressive noninclusion subpopulation patients, less relatively few patients. The any (or chemotherapy) sensitivity mutations present so reducing dose compensate radiosensitive will necessarily result undertreatment tumor.