Development of Immunotherapy Combination Strategies in Cancer
作者： Hussein A. Tawbi , Justin T. Moyers , Timothy A. Yap , Michael A. Curran , Weiyi Peng
DOI: 10.1158/2159-8290.CD-20-1209
关键词:
摘要: Harnessing the immune system to treat cancer through inhibitors of CTLA4 and PD-L1 has revolutionized landscape cancer. Rational combination strategies aim enhance antitumor effects immunotherapies, but require a deep understanding mechanistic underpinnings robust preclinical clinical drug development strategies. We review current approved immunotherapy combinations, before discussing promising combinatorial approaches in trials detailing innovative model systems being used develop rational combinations. also discuss promise high-order as well novel biomarker trial SIGNIFICANCE: Although immune-checkpoint are dual checkpoint strategies, with cytotoxic chemotherapy angiogenesis for multiple cancers, patient benefit remains limited. Innovative required guide ranging from improvements tumor biomarker-driven
aacrjournals.org
sci-hub.st 参考文章(155)
Enrique Alvarez, B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model Tumor Models in Cancer Research. pp. 79- 95 ,(2011) , 10.1007/978-1-60761-968-0_4
Juan J. Rojas, Padma Sampath, Weizhou Hou, Steve H. Thorne, Defining Effective Combinations of Immune Checkpoint Blockade and Oncolytic Virotherapy Clinical Cancer Research. ,vol. 21, pp. 5543- 5551 ,(2015) , 10.1158/1078-0432.CCR-14-2009
C Kanellopoulos-Langevin, R Asofsky, D H Sachs, R M Merwin, K J Kim, Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties Journal of Immunology. ,vol. 122, pp. 549- 554 ,(1979)
Krithika N. Kodumudi, Amy Weber, Amod A. Sarnaik, Shari Pilon-Thomas, Blockade of myeloid-derived suppressor cells after induction of lymphopenia improves adoptive T cell therapy in a murine model of melanoma. Journal of Immunology. ,vol. 189, pp. 5147- 5154 ,(2012) , 10.4049/JIMMUNOL.1200274
Herbert S. Schwartz, Gerald B. Grindey, Adriamycin and Daunorubicin: A Comparison of Antitumor Activities and Tissue Uptake in Mice following Immunosuppression Cancer Research. ,vol. 33, pp. 1837- 1844 ,(1973)
Vincenzo Bronte, Dennis Panicali, Nicholas P. Restifo, Linda Gritz, Steven A. Rosenberg, Michael Wang, Pauline W. Chen, Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen. Journal of Immunology. ,vol. 154, pp. 4685- 4692 ,(1995)
Kevin J. Curran, Hollie J. Pegram, Renier J. Brentjens, Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions Journal of Gene Medicine. ,vol. 14, pp. 405- 415 ,(2012) , 10.1002/JGM.2604
Edmund K. Moon, Raghuveer Ranganathan, Evgeniy Eruslanov, Soyeon Kim, Kheng Newick, Shaun O'Brien, Albert Lo, Xiaojun Liu, Yangbing Zhao, Steven M. Albelda, Blockade of Programmed Death 1 Augments the Ability of Human T Cells Engineered to Target NY-ESO-1 to Control Tumor Growth after Adoptive Transfer Clinical Cancer Research. ,vol. 22, pp. 436- 447 ,(2016) , 10.1158/1078-0432.CCR-15-1070
Effects of Donor Age on Neoplastic Transformation of Adult Mouse Bladder Epithelium In Vitro Journal of the National Cancer Institute. ,vol. 62, pp. 1017- 1023 ,(1979) , 10.1093/JNCI/62.4.1017
Katherine B. Chiappinelli, Pamela L. Strissel, Alexis Desrichard, Huili Li, Christine Henke, Benjamin Akman, Alexander Hein, Neal S. Rote, Leslie M. Cope, Alexandra Snyder, Vladimir Makarov, Sadna Buhu, Dennis J. Slamon, Jedd D. Wolchok, Drew M. Pardoll, Matthias W. Beckmann, Cynthia A. Zahnow, Taha Merghoub, Timothy A. Chan, Stephen B. Baylin, Reiner Strick, Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses Cell. ,vol. 162, pp. 974- 986 ,(2015) , 10.1016/J.CELL.2015.07.011