The personal genome project.

摘要: Mol Syst Biol. 1: 2005.0030 Large potential benefits for systems biology reside in applications to human health and identity. To develop our community's skills these directions, ready access highly integrated comprehensive genome phenome data sets is extremely important increasingly feasible technically. The few 'functional genomics' available today tend be isolated from one another. Some of the tools needed break through this impasse are addressed below context a Personal Genome Project (PGP) as natural successor Human (HGP)—two recent buds ancient field genetics. From my first interaction with Wally Gilbert 1976, it seemed that large (but appealing) leap would go his new method sequencing 30 bp segments get everyone's full sequenced. Six billion base pairs six people had nice ring it. This was still merely fantasy when we published paper called 'Genomic Sequencing' 1984 (Church Gilbert, 1984) conspired create 3 dollar HGP later year (Cook‐Deegan, 1989). For subsequent 16 years, radical technology development (while kept alive 'back‐rooms') clearly minor funding priority relative 'production' sequencing. However, by 2001, criticisms old grew call affordable personal genomes became irresistible (Jonietz, 2001). In early 2004, NIH‐NHGRI posted request applications, October 2004 August 2005, announced grant awards totaling $70 million leading sequences $100 000 5 years $1000 10 (http://www.nih.gov/news/pr/aug2005/nhgri‐08.htm). As if motivation were not already high enough, at Sequencing & Analysis Conference Hilton Head (October …