Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders.

摘要: Atypical antipsychotics are emerging as the first-line pharmacologic treatment for irritability (i.e., aggression, self-injurious behavior, and severe tantrums) in children adolescents with autistic other pervasive developmental disorders. Results from placebo-controlled open-label studies of clozapine, risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole this subject population reviewed. Additional trials longer-term safety tolerability needed.