Influence of solid dispersion technique combination on dissolution of tanshinone IIA.

摘要: OBJECTIVE To compare the influence on dissolution of tanshinone IIA (TS IIA) solid dispersions in complex carriers and single, which used preparation TS dispersions, further enhance IIA. METHOD The were prepared by solvent technique with polyvinylpyrrolidone K30 (PVPK30), poloxamer188 (F68) combination PVPK30 F68 as carriers, respectively. physical characteristics was studied using differential scanning calorimetry (DSC). Dissolution rates small cup method (CHP XC III). solubility pure drug form determined HPLC method. RESULT DSC analysis suggested that dispersed an amorphous F68. profile could be described Weibull equation (R>0.99). For tested three carries, Td value (calculated time to 63.2% total release according equation) (90.40 +/- 2.82) min, (204.5 8.20) min (25.83 0.13) PVPK30/F68-TS dispersion resulted a significant increase compared PVPK30-TS F68-TS (P<0.01). CONCLUSION As single use or F68, improve rate significantly application technology should paid more attention improvement poorly soluble drugs future.