Cytogenetic analysis of a benzpyrene induced osteosarcoma in the rat (Rattus norvegicus)
作者： H. Schmidt , F.-W. Rath
DOI: 10.1016/0165-4608(93)90019-I
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摘要: A cytogenetic comparison of primary and transplant tumor cell-lines, both originating from a benzpyrene induced osteosarcoma, with normal rat cell-lines (Rattus norvegicus) is presented here. In all tested, the number chromosomes was increased by one or two. Using Giemsa-banding, structural chromosomal changes, i.e. Robertsonian translocation t(4;4)(q10;q10) an interstitial deletion del(6)(q11q16) could be recorded. Furthermore, staining nucleolus organizer regions (NORs) revealed shift in NOR activity chromosome 11 to 12 decrease at 3.
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