In vivo assessment of neurotransmitters and modulators with magnetic resonance spectroscopy: application to schizophrenia.
作者： S. Andrea Wijtenburg , Shaolin Yang , Bernard A. Fischer , Laura M. Rowland
DOI: 10.1016/J.NEUBIOREV.2015.01.007
关键词:
摘要: Abstract In vivo measurement of neurotransmitters and modulators is now feasible with advanced proton magnetic resonance spectroscopy (1H MRS) techniques. This review provides a basic tutorial MRS, describes the methods available to measure brain glutamate, glutamine, γ-aminobutyric acid, glutathione, N-acetylaspartylglutamate, glycine, serine at field strengths 3 T or higher, summarizes neurochemical findings in schizophrenia. Overall, 1H MRS holds great promise for producing biomarkers that can serve as treatment targets, prediction disease onset, illness exacerbation schizophrenia other diseases.
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