Tight Junction Disruption and Recovery after Sublethal γ Irradiation

摘要: Ilea from sublethally irradiated, adult rats were prepared for freeze-fracture and lanthanum tracer study to investigate the alterations that occur in structure function of intestinal permeability barrier. Some tight junction structures determined be focally disrupted between days 1 5 postirradiation using technique. Alterations mean depth apical appeared correlate with epithelium tracer. The occurrence junctional fragments over extensive areas lateral membrane fracture faces observed during disruption recovery phases manifested as linear macular junctions extended basally (zonula occludens) far basal lamina. These proliferative thought eventually removed by phagocytosis since numerous could cytoplasmic vesicles 3 7 after irradiation Lanthanum tracer, which was added only lumen fixation electron microscopy, found extracellular spaces some goblet adjacent absorptive epithelial cells preparations irradiated rats. Leaky postirradiation, thereupon returning control levels.