Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease.

摘要: To clarify the distribution, morphology, and density of amyloid deposits in patients with Alzheimer's disease (AD), tissue sections from various areas central nervous system 14 AD 20 nondemented aged controls were investigated immunohistochemically using anti-beta protein antiserum. beta-protein present not only cores senile plaques vascular wall (amyloid angiopathy), but also sized plaque-shaped fibrillary, perivascular, subpial, subependymal deposits. Amyloid found mainly cerebral cortex controls, while they distributed widely regions that affected controls. The positivity was 100% cortex, hippocampus, amygdala, thalamus, caudate nucleus, claustrum, hypothalamus, nucleus basalis Meynert, cerebellar cortex. Putamen brain-stem nuclei frequently, spinal cord, dentate globus pallidus sometimes (less than 50%) affected. This result provides an evidence is a amyloidosis system. An assessment distribution should prove to be useful for histopathologic diagnosis AD.