Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes.
作者： Mizuho Nakayama , Katsuya Sakai , Atsuko Yamashita , Takahiro Nakamura , Yoshinori Suzuki
DOI: 10.1016/J.CYTO.2013.04.006
关键词:
摘要: Met/hepatocyte growth factor (HGF) receptor plays a definitive role in hepatocyte proliferation and liver regeneration. Phosphorylation of Ser985 Met (Met-Ser985) down regulate tyrosine phosphorylation activation Met. However, mechanism inactivation by Met-Ser985 its biological significance on regeneration are not well known. Here, we investigated hepatocytes liver. In primary cultured hepatocytes, HGF-dependent mitogenesis were suppressed when was phosphorylated. Cell surface decreased upon through endocytosis, suggesting which could be suppressed. mice, HGF induced injured livers, but non-injured livers. after injury associated with phosphorylation/activation during These results indicate that is regulated reciprocally to the following injury. Our study suggests regulatory response quiescence, injury,
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