Endogenous tissue-type plasminogen activator and risk of myocardial infarction

摘要: Abstract Endogenous tissue-type plasminogen activator (tPA) has been hypothesised to be a marker of baseline fibrinolytic capacity. We therefore tested whether tPA antigen is associated with the occurrence future myocardial infarction (Ml) among apparently healthy individuals. concentrations were measured at in plasma samples from 231 men Physicians' Health Study cohort who later developed Ml, and an equal number controls matched for age smoking habit remained free reported cardiovascular disease during follow-up 60·2 months. In crude matched-pair analyses, higher cases than (p=0·03) strongly risk Ml. Specifically, relative risks developing first Ml lowest (referent) highest quintiles 1·00, 1·27, 1·75, 1·88, 2·81 (p trend 0·0008, 95% Cl fifth as compared quintile 1·47 5·37, p=0·002). Analyses which adjusted factors that affect progression atherosclerosis, particularly HDL-cholesterol, abolished statistical significance this association, finding suggests elevations are result rather cause atherosclerotic coronary disease. These prospective data suggest endogenous increase consequence important preclinical atherosclerosis may