Alterations in adaptive immunity persist during long-duration spaceflight.

摘要: It is currently unknown whether immune system alterations persist during long-duration spaceflight. In this study various adaptive parameters were assessed in astronauts at three intervals 6-month spaceflight on board the International Space Station (ISS). To assess phenotypic and functional participating orbital Blood was collected before, during, after flight from 23 ISS expeditions. In-flight samples returned to Earth within 48 h of collection for immediate analysis. Assays included peripheral leukocyte distribution, T-cell function, virus-specific immunity, mitogen-stimulated cytokine production profiles. Redistribution subsets occurred flight, including an elevated white blood cell (WBC) count CD8+ maturation. A reduction general function (both CD4+ CD8+) persisted duration spaceflights, with differential responses between mitogens suggesting activation threshold shift. The percentage T cells capable producing IL-2 depressed landing. Significant reductions IFNγ, IL-10, IL-5, TNFα, IL-6 Following lipopolysaccharide (LPS) stimulation, IL-10 reduced, whereas IL-8 increased flight. data indicated that This phenomenon, absence appropriate countermeasures, has potential increase specific clinical risks crewmembers exploration-class deep space missions. Long voyages could pose health resulting changes astronauts' systems, warn NASA scientists. team led by Clarence Sams NASA's Johnson Center Houston analyzed taken six-month stays Station. They detected a variety persistent numbers functions, altered signaling molecules mediate response. During extended flights, such as missions Mars, these cause medical problems susceptibility infectious disease, allergies, wound healing. also possible risk cancer or development autoimmune disease would be elevated. characterization represents first step determining need immune-specific countermeasures improve safety