The Complement System in Systemic Lupus Erythematosus

摘要: Abstract Complement is intimately engaged in systemic lupus erythematosus (SLE). Here, we provide a comprehensive account of how complement involved the etiology, disease onset, pathogenesis, diagnosis, and management human SLE. We have two primary objectives. The first to summarize current status our thoughts about using as biomarker facilitate clinical second knowledge on genetic deficiency contributes causatively functional insufficiency because polymorphisms or acquired protein deficiencies increases predisposition modifies course outcomes. field research SLE entering an exciting time with wealth new information (a) crystal solution structures native activated individual proteins well that large molecular complexes, (b) identification variants their consequences predisposing lupus, (c) utility inhibitors ameliorate complement-mediated tissue injuries, (d) trials hematopoietic stem cells cure deficiency. has provided important breakthroughs relative etiology pathogenesis Hopefully, therapeutic interventions modulating complement's role will favorably impact this chronic affects millions individuals.