Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk
作者： Zheng Zhang
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摘要: 0.84(95%CI,0.83-0.85);andPPV3,0.16(95%CI,0.12-0.21).Formammographyalone, sensitivitywas0.52(95%CI,0.40-0.64);specificity,0.91(95%CI,0.90-0.92);andPPV3, 0.38 (95% CI, 0.28-0.49; P.001 all comparisons). Of the MRI participants, 16 women (2.6%) had breast cancer diagnosed. The supplemental yield of was 14.7 per 1000 (95%CI,3.5-25.9;P=.004).SensitivityforMRIandmammographyplusultrasoundwas 1.00 0.79-1.00); specificity, 0.65 0.61-0.69); and PPV3, 0.19 0.11-0.29). For mammography ultrasound, sensitivity 0.44 0.200.70, P=.004); specificity 0.84 0.81-0.87; P.001); 0.18 0.08to0.34;P=.98).Thenumberofscreensneededtodetect1cancerwas127(95%CI, 99-167)formammography;234(95%CI,173-345)forsupplementalultrasound;and68 39-286) for after negative ultrasound results. Conclusion addition screening or to in at increased risk resulted not only a higher detection but also an increase false-positive findings.
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