Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites

摘要: Intensive research in the author's laboratory had culminated determination and synthesis of all antigenic sites myoglobin 1975 lysozyme 1978. Very recently most serum albumin were also localized synthesized. These investigations provided first unique insight into molecular features responsible for immune recognition protein antigens factors which determine regulate antigenicity sites. But moreover, these studies have charted a multi-approach chemical strategy investigation synthetic duplication binding Furthermore, concept ‘surface-simulation’ synthesis, we introduced developed during our structure lysozyme, has remarkable dimension unlimited versatility mimicking any type In this concept, spatially adjacent residues site are linked directly via peptide bonds with appropriate spacers single does not exist but mimicks surface region it. This proved to be powerful opened up many untapped avenues investigation, perhaps manipulation variety activities. fact, representing other activities (including antibody combining sites) or now being mimicked synthetically by surface-simulation synthesis.