Correlation between overexpression of c-met gene and the progression of gastric cancer.
作者： Y Yonemura , M Kaji , Y Hirono , S Fushida , K Tsugawa
DOI: 10.3892/IJO.8.3.555
关键词:
摘要: The c-met oncogene encodes a receptor of hepatocyte growth factor (HGF), which has both mitogenic and motogenic activities. We have studied the gene expression in gastric cancer by immunohistochemical method using an antibody specific to beta-chain. immunoreactivity was preferentially localize on cell membrane, 55 (43%) 127 primary cancers showed immunoreactivity. Strong correlation found between large tumors, lymph node involvement, serosal invasion, as well peritoneal dissemination. Furthermore, positive tumors had tendency metastasize more distant sites. Regarding macroscopic type, Borrmann type 4 highest incidence (12/16, 76%) expression. Patients with tumor ran significantly poorer prognosis than those negative one. These results indicate that protein participates progression invasion stomach cancer, tissue status is useful biological marker cancer.
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