Severe Hemodilution With Hydroxyethyl Starch and Dextrans

摘要: DEXTRANS have been in clinical use as plasma expanders for a number of years. Following large infusions, hemorrhage is not infrequent and numerous investigations the effects dextrans on blood coagulation factors hemostatic mechanisms made.1-9One consistent finding has prolongation bleeding time which seemed out proportion to reduction platelet count. Other findings include reductions various (which may exceed those anticipated simple dilution) an inhibitory effect release thromboplastic factor (platelet 3). The experiments performed by Takaori Safar10,11offered opportunity reexplore massive infusions dextran compare 40 experimental expander: hydroxyethyl starch (HES). Methods Coagulation were measured previously described methods.12,13Hematocrit reading sedimentation rate Wintrobe's methods.14