Development and Characterization of High-Affinity Anti-Topotecan IgG and Fab Fragments
作者： Jin Chen , Joseph P. Balthasar
DOI: 10.1002/9780470571224.PSE316
关键词:
摘要: Anti-drug antibodies are increasingly being used within an inverse targeting strategy to increase the pharmacokinetic and therapeutic selectivity of intraperitoneal (i.p.) chemotherapy. The anti-topotecan (TPT) have demonstrated high affinity sufficient purity for use in evaluating their “inverse targeting” strategies optimize TPT i.p. This article describes development hybridomas secreting monoclonal against TPT, production, purification, characterization, pharmacokinetics anti-TPT antibody Fab fragments. Keywords: anti-topotecan antibodies; intraperitoneal chemotherapy; inverse targeting; pharmacokinetics
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