The Utilization of Online Gene Expression Data Repositories to Generate Testable Hypotheses in the Laboratory

摘要: Copyright: © 2013 Stamper BD. This is an open-access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided original author source are credited. Since their invention late 1980s, microarrays have revolutionized our understanding gene expression patterns important role transcription plays human health disease. As popularity high-throughput hybridization arrays has increased over years, public’s demand for access to array datasets as well. In response this demand, National Center Biotechnology Information (NCBI) established Gene Expression Omnibus (GEO) 2000, can be accessed at http://www.ncbi. nlm.nih.gov/geo [1]. Two years later, European Bioinformatics Institute (EBI) ArrayExpress, http://www.ebi.ac.uk/Arrayexpress [2]. Currently, these repositories hold 1 million samples combined. Recent updates on both GEO ArrayExpress were published earlier year [3,4].