In vitro evaluation of a chitosan membrane cross-linked with genipin
作者： Fwu-Long Mi , Yu-Chiun Tan , Huang-Chien Liang , Rong-Nan Huang , Hsing-Wen Sung
DOI: 10.1163/156856201753113051
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摘要: The study was to evaluate the characteristics of a chitosan membrane cross-linked with naturally-occurring cross-linking reagent, genipin. This newly-developed genipin-cross-linked may be used as an implantable drug-delivery system. without (fresh) and glutaraldehyde-cross-linked were controls. test membranes evaluated their degree, swelling ratio, mechanical properties, antimicrobial activity, cytotoxicity, degradability. It found that using genipin increased its ultimate tensile strength but significantly reduced strain-at-fracture ratio. There no significant difference in activity between fresh counterpart. Additionally, results showed had less cytotoxicity slower degr...
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sci-hub.se 参考文章(29)
Emad Eldin Hassan, Roy C. Parish, James M. Gallo, Optimized Formulation of Magnetic Chitosan Microspheres Containing the Anticancer Agent, Oxantrazole Pharmaceutical Research. ,vol. 9, pp. 390- 397 ,(1992) , 10.1023/A:1015803321609
George A. F. Roberts, Kathryn E. Taylor, Chitosan gels, 3. The formation of gels by reaction of chitosan with glutaraldehyde Macromolecular Chemistry and Physics. ,vol. 190, pp. 951- 960 ,(1989) , 10.1002/MACP.1989.021900504
S.R. Jameela, A. Jayakrishnan, Glutaraldehyde cross-linked chitosan microspheres as a long acting biodegradable drug delivery vehicle: studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle Biomaterials. ,vol. 16, pp. 769- 775 ,(1995) , 10.1016/0142-9612(95)99639-4
S.H Pangburn, P.V Trescony, J Heller, Lysozyme degradation of partially deacetylated chitin, its films and hydrogels. Biomaterials. ,vol. 3, pp. 105- 108 ,(1982) , 10.1016/0142-9612(82)90043-6
Hsing-Wen Sung, Rong-Nan Huang, Lynn L.H. Huang, Chen-Chi Tsai, In vitro evaluation of cytotoxicity of a naturally occurring cross-linking reagent for biological tissue fixation Journal of Biomaterials Science-polymer Edition. ,vol. 10, pp. 63- 78 ,(1999) , 10.1163/156856299X00289
J. Akbuǧa, G. Durmaz, Preparation and evaluation of cross-linked chitosan microspheres containing furosemide International Journal of Pharmaceutics. ,vol. 111, pp. 217- 222 ,(1994) , 10.1016/0378-5173(94)90344-1
Kenji Tomihata, Yoshito Ikada, In vitro and in vivo degradation of films of chitin and its deacetylated derivatives Biomaterials. ,vol. 18, pp. 567- 575 ,(1997) , 10.1016/S0142-9612(96)00167-6
Riccardo A.A. Muzzarelli, Biochemical significance of exogenous chitins and chitosans in animals and patients Carbohydrate Polymers. ,vol. 20, pp. 7- 16 ,(1993) , 10.1016/0144-8617(93)90027-2
Carmen Remuñán-López, Roland Bodmeier, Mechanical, water uptake and permeability properties of crosslinked chitosan glutamate and alginate films Journal of Controlled Release. ,vol. 44, pp. 215- 225 ,(1997) , 10.1016/S0168-3659(96)01525-8
N.R. Sudarshan, D.G. Hoover, D. Knorr, Antibacterial action of chitosan Food Biotechnology. ,vol. 6, pp. 257- 272 ,(1992) , 10.1080/08905439209549838