Neutrophilic Hypersegmentation Without Macrocytic Anemia

摘要: In five months of examining some 25,000 blood smears hospital and clinic patients, 200 patients were found whose had hypersegmented neutrophiles without macrocytosis the erythrocytes. Sixty-five these subsequently received adequate laboratory work-up. Seven proved to have a bacterial inhibitor in their serum which interfered with microbiological assay folic acid. Of six normal B-12 levels. remaining 58, 45 deficiency folate, vitamin or both. 13, no such could be established. these, seven uremic. It is concluded that additional effort required search carefully for hypersegmentation, even absence erythroid macrocytosis, thoroughly justified, large percentage those are will prove important deficiencies folate B-12,