Inflammation and Frailty in Older Women
作者： Sean X. Leng , Qian-Li Xue , Jing Tian , Jeremy D. Walston , Linda P. Fried
DOI: 10.1111/J.1532-5415.2007.01186.X
关键词:
摘要: OBJECTIVES: To evaluate relationships between white blood cell (WBC) count and interleukin-6 (IL-6) prevalent frailty. DESIGN: Cross-sectional study. SETTING: Two population-based studies, the Women's Health Aging Studies (WHAS) I II, Baltimore, Maryland. PARTICIPANTS: Five hundred fifty-eight women aged 65 to 101 from WHAS 548 70 79 merged II cohorts. MEASUREMENTS: Frailty was determined using validated screening criteria. WBC counts IL-6 levels were measured standard laboratory methods. Odds ratios (ORs) for frailty evaluated across tertiles of baseline levels, adjusting age, race, education, body mass index, smoking status. RESULTS: In I, those in top tertile had ORs 4.25 (95% confidence interval (CI)=1.89–9.58) 3.98 CI=1.76–9.00), respectively, (both P<.001). combined models, participants an OR 3.15 CI=1.34–7.41), (P<.01), 2.81 CI=1.19–6.64), (P<.05). Furthermore, 9.85 CI=3.04–31.99), middle/top 5.40 CI=1.83–15.92) (P<.001, trend test) frailty. These results II. CONCLUSION: Higher independently associated with community-dwelling older women.
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