Analytical goal-setting for monitoring patients when two analytical methods are used.

摘要: Serial results from an individual are often obtained using more than one method. Results should be transferable over time and locale. Every method has inherent analytical error, goals required to delineate the maximum allowable random (imprecision) systematic (inaccuracy, bias) errors facilitate optimal patient care. Based on Harris's proposal [Am J Clin Pathol 1979;72:374-82] that desirable imprecision less or equal one-half within-subject biological variation, if methods have negligible imprecision, then bias between two used for monitoring is one-third of variation. A general model been developed relates imprecisions methods, them, Applying formula derived in specific clinical situations which a known change serial (occurring at stated probability) stimulates action allows difference them determined quantitatively.