Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in nmr diagnosis and radiodiagnosis and radiotherapy
作者： Thomas Frenzel , Heribert Schmitt-Willich , Heiko Schirmer , Hans Bauer , Detlev Sulzle
DOI:
关键词:
摘要: The invention relates to conjugates comprised of macrocyclic metal complexes with biomolecules and the production thereof. are suited for use as contrast agents in NMR diagnosis radiodiagnosis radiotherapy. A high relaxivity is achieved a fine tuning made possible by special liganding macrocycles.
lens.org 参考文章(5)
Mark Woods, Silvio Aime, Mauro Botta, Judith A. K. Howard, Janet M. Moloney, Michel Navet, David Parker, Marc Port, Olivier Rousseaux, Correlation of Water Exchange Rate with Isomeric Composition in Diastereoisomeric Gadolinium Complexes of Tetra(carboxyethyl)dota and Related Macrocyclic Ligands Journal of the American Chemical Society. ,vol. 122, pp. 9781- 9792 ,(2000) , 10.1021/JA994492V
Peter Caravan, Jeffrey J. Ellison, Thomas J. McMurry, Randall B. Lauffer, Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications Chemical Reviews. ,vol. 99, pp. 2293- 2352 ,(1999) , 10.1021/CR980440X
Michael F. Tweedle, Xun Zhang, Ramachandran S. Ranganathan, Rajesh Shukla, Peter C. Ratsep, Radhakrishna Pillai, Enhanced relaxivity monomeric and multimeric compounds ,(1995)
Kumiko Iwai, Makoto Azuma, Shigemi Seri, Kan Kubomura, Tetraazacyclododecane tetraacetic acid derivatives and the use thereof as diagnostic agents ,(1993)
Ruediger Lawaczeck, Bernd Raduechel, Johannes Platzek, Metal macrocycles for two-step forms of radiotherapy ,(2000)