Process for production of heterodimers of glutamic acid

摘要: A manufacturing process for the preparation of radiolabeled compounds formula (I) includes reacting (II) with a source readionuclide halogen in presence an oxidant under acidic condition, wherein: *I is 123 I, 124 125 I or 131 I; R lower alkyl, optionally substituted one more fluorine atoms; Q C(O), O, NR′, S, S(O) 2 , C(O) (CH ) p ; Y R′ H, Z C 1 -C 4 benzyl, benzyl trialkylsilyl; m 0, 1, 2, 3, 5; n 4, 5 6; and 6.