摘要: The lymphomas, as a group, are among the most responsive of neoplastic diseases man falls heir to. modern period chemotherapy lymphomas began in early 1940’s with appearance prototype alkylating agent, nitrogen mustard. While these agents have proven useful therapy diseases, there is no hard evidence that life patients has been significantly prolonged. In twenty-five years followed introduction mustard, oncologists concerned primarily identification new active drugs, at first agents, but then other classes antitumor drugs without cross resistance to agents. addition, great deal effort spent accumulating knowledge about optimum way employing each drug. Now several independent antilymphoma activity available, recent studies more properly best ways employ them either used concomitantly, or sequence cyclical fashion, prolong patients, if possible, totally eradicate disease.