Caspase inhibitors, especially caspase 3 inhibitors, for the treatment of influenza
作者： Stephan Pleschka , Stefan Ludwig , Hans-Harald Sedlacek , Oliver Planz
DOI:
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摘要: The invention relates to the use of at least one caspase inhibitor, especially a 3 for producing pharmaceutical composition prophylaxis and/or treatment viral infection, an infection with negative-strand RNA virus, preferably influenza infection. also test system identifying suitable active ingredients.
lens.org 参考文章(7)
C W Olsen, J C Kehren, N R Dybdahl-Sissoko, V S Hinshaw, bcl-2 alters influenza virus yield, spread, and hemagglutinin glycosylation. Journal of Virology. ,vol. 70, pp. 663- 666 ,(1996) , 10.1128/JVI.70.1.663-666.1996
J Bertoglio, J Bréard, N Moulian, C Renvoizé, R Roger, Bcl-2 expression in target cells leads to functional inhibition of caspase-3 protease family in human NK and lymphokine-activated killer cell granule-mediated apoptosis. Journal of Immunology. ,vol. 159, pp. 126- 134 ,(1997)
Lex M. Cowsert, Hong Zhang, Antisense modulation of caspase 3 expression ,(2001)
Walter J Wurzer, Oliver Planz, Christina Ehrhardt, Martin Giner, Tobias Silberzahn, Stephan Pleschka, Stephan Ludwig, Caspase 3 activation is essential for efficient influenza virus propagation The EMBO Journal. ,vol. 22, pp. 2717- 2728 ,(2003) , 10.1093/EMBOJ/CDG279
Takenori Takizawa, Chizuru Tatematsu, Kayoko Ohashi, Yoshinobu Nakanishi, Recruitment of apoptotic cysteine proteases (caspases) in influenza virus-induced cell death. Microbiology and Immunology. ,vol. 43, pp. 245- 252 ,(1999) , 10.1111/J.1348-0421.1999.TB02400.X
J.-W. Park, Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity Carcinogenesis. ,vol. 22, pp. 1633- 1639 ,(2001) , 10.1093/CARCIN/22.10.1633
Stephan Pleschka, Stephan Ludwig, Hans-Harald Sedlacek, Oliver Planz, Pharmaceutical composition for the prophylaxis and/or treatment of virus diseases ,(2002)