The Metastatic Cell : behaviour and biochemistry

摘要: Part 1 The tumour cell phenotype: what is a tumour? general aspects of growth how are tumours classified? grading and staging causes tumours? do cells differ from normal cells? characteristic features the significance immune system in development - immunosurveillance induction dormancy. 2 invasive metastatic behaviour malignant cells: invasion metastisis "In Vivo" resistance to problem metastasis process principles spread carcinomas sarcomas blood structure vessels functional properties vascular endothelium haemodynamics extracellular matrix lymphatic extravasation leukocytes essential steps nature pattern role enzymes status. 3 models for study metastasis: model systems transplantable lines "Artificial" "Spontaneous" B16 melanoma murine nude mouse as transparent studying during embryonic chick metastasis. 4 Vitro" two dimensional confrontation monolayers filters electrophysiological assessment collagen gels organs, tissue fragments aggregates comparison 5 adhesive locomotory adhesion measuring mechanisms cell-substrate modulation oncogenes homologies within different locomotion chemotaxis chemokinesis haptotaxis effects on host locomotion-related functions locomotion, 6 Reflections new horizons: genes, their regulation malignancy cancer transgenic mice reversibility effective treatment observations speculations an ultimate understanding?.