Cigarette smoking and maternal-child HIV transmission.

摘要: We investigated the association of cigarette smoking with maternal-child HIV transmission, adjusting for illicit drug use, maternal clinical status, and delivery factors. Vital statistics birth data were linked to New York State Medicaid HIV/AIDS Research Database HIV-infected women delivering a liveborn singleton from 1988 through 1990. Follow-up these children was accomplished by > or = 2 years after birth, their status ascertained clinically based classification. The adjusted relative risk hazard (RH) transmission factors determined Cox models. overall 24.5% 901 pairs. Smokers comprised 40% on (n 768); rate 31% versus 22% nonsmokers (p 0.02). In entire cohort, RH smokers 1.45 (95% confidence interval [CI] 1.07-1.96); among advanced HIV, even higher (RH 1.71; 95% CI 1.14-2.58). Users cocaine (15% cohort) mixed unspecified drugs (28%) had rates in unadjusted analysis (33%, p 0.06 31%, respectively); adjustment other factors, neither 1.04 0.66-1.63)) nor use 1.13 0.75-1.70)) significantly associated transmission. Our document an during pregnancy increased that can be added growing list complications caused smoking.