Human placenta: A direct target for cocaine action

作者: V. Ganapathy , F.H. Leibach

DOI: 10.1016/S0143-4004(05)80181-X

关键词:

摘要: Summary Use of cocaine during pregnancy is known to have harmful effects on the mother and her fetus. Currently available models describing pathogenesis these focus involvement target systems, primarily noradrenaline transporter, in The placenta which lies between fetus considered only as a ‘silent observer’ whole process cocaine-induced complications pregnancy. Recent studies have, however, shown that expresses several proteins such serotonin sigma receptor. functions are significantly impaired presence at concentrations exist plasma users. These clearly show itself direct for action interaction with its plays an important role developing

参考文章(62)
Stanley L. Barnwell, B. V. Rama Sastry, Depression of Amino Acid Uptake in Human Placental Villus by Cocaine, Morphine and Nicotine Springer, Boston, MA. pp. 101- 120 ,(1984) , 10.1007/978-1-4684-1191-1_9
Lauder Jm, Zimmerman Ef, Sites of serotonin uptake in epithelia of the developing mouse palate, oral cavity, and face: possible role in morphogenesis. Journal of Craniofacial Genetics and Developmental Biology. ,vol. 8, pp. 265- ,(1988)
D.R. Cool, F.H. Leibach, V.K. Bhalla, V.B. Mahesh, V. Ganapathy, Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). Journal of Biological Chemistry. ,vol. 266, pp. 15750- 15757 ,(1991) , 10.1016/S0021-9258(18)98473-5
Richard J. Grand, John B. Watkins, Frank M. Torti, Development of the Human Gastrointestinal Tract: A Review Gastroenterology. ,vol. 70, pp. 790- 810 ,(1976) , 10.1016/S0016-5085(76)80277-6
D F Balkovetz, C Tiruppathi, F H Leibach, V B Mahesh, V Ganapathy, Evidence for an Imipramine-sensitive Serotonin Transporter in Human Placental Brush-border Membranes Journal of Biological Chemistry. ,vol. 264, pp. 2195- 2198 ,(1989) , 10.1016/S0021-9258(18)94161-X
F. H. Leibach, Vadivel Ganapathy, V. B. Mahesh, L. D. Jayanthi, Sammanda Ramamoorthy, Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells Journal of Biological Chemistry. ,vol. 269, pp. 14424- 14429 ,(1994) , 10.1016/S0021-9258(17)36640-1
C. Diana Morgan, M. Sandler, M. Panigel, Placental transfer of catecholamines in vitro and in vivo American Journal of Obstetrics and Gynecology. ,vol. 112, pp. 1068- 1075 ,(1972) , 10.1016/0002-9378(72)90182-2
Emmalee S. Bandstra, Gene Burkett, Maternal-fetal and neonatal effects of in utero cocaine exposure. Seminars in Perinatology. ,vol. 15, pp. 288- 301 ,(1991) , 10.5555/URI:PII:014600059190005B
R R Matsumoto, W D Bowen, F O Walker, J M Walker, B De Costa, K C Rice, Sigma receptors: biology and function. Pharmacological Reviews. ,vol. 42, pp. 355- 402 ,(1990)