Practical synthesis of biaryl colchicinoids containing 3′,4′-catechol ether-based A-rings via Suzuki cross-coupling with ligandless palladium in water☆
作者： Amy Morin Deveau , Timothy L. Macdonald
DOI: 10.1016/J.TETLET.2003.11.016
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摘要: Abstract Eight new biaryl colchicinoids containing 3′,4′-methylene or benzodioxy ether bridges were synthesized. The key synthetic step employed a ligandless, aqueous Suzuki cross-coupling reaction catalyzed by Pd(OAc)2 with tetrabutylammonium bromide (TBAB) and potassium carbonate (K2CO3). products typically formed in 5–30 min always less than 1 h.
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