Taste masking of diclofenac sodium using microencapsulation

摘要: This study addresses how to mask the undesirable taste of diclofenac sodium (DS) without interfering with an adequate rate drug release. DS microcapsules were successfully prepared using a system ethylcellulose (EC)-toluene-petroleum ether. The was optimized by construction phase diagram and determination amount EC precipitated under different solvent:non-solvent ratios determine most appropriate conditions for preparing good microcapsules. Microcrystalline cellulose (Avicel) lactose mixed powder converted into spherical cores wet agglomeration technique which facilitated coacervation formation thin uniform microcapsule walls. Diethylphthalate (DEP) Polyethyleneglycol 600 (PEG) in concentrations (20 or 40% w/w) used as plasticizers impart better elasticity evaluated released against crushed commercial enteric coated tablet (Voltaren). panel 10 volunteers. results revealed that optimum ratio required 1:2. Microcapsules containing PEG 20% DEP showed faster release compared obtained from other tablets palatability significantly improved microencapsulation. extent masking influenced core:wall ratio, presence additives within core, type concentration plasticizer initial core size.