Ontogeny of corticosteroid-binding globulin biosynthesis in the rat.

摘要: In plasma, glucocorticoids are transported by corticosteroid-binding globulin (CBG), which is synthesized primarily in the liver. Plasma levels of maternal and fetal CBG fluctuate during gestation, this may be due to changes biosynthesis and/or clearance protein. We have, therefore, studied ontogeny rat using a solution hybridization assay measure hepatic mRNA levels. The results indicate that concentration exceptionally high 15-day-old livers (55.1 pg mRNA/μg total RNA), but declines very low at birth (day 21). During same period, remained relatively constant (18.9–23.1 RNA). Hepatic were barely detectable 1 week after birth, sex difference was apparent 2 weeks age, with higher female livers. Although adult attained 3 serum concentrations did not reach values fo...