Synthesis and Degradation of pH-Sensitive Linear Poly(amidoamine)s

摘要: The design and synthesis of a family cationic, pH-sensitive poly(amidoamine)s are reported. Acetal or ketal linkages were incorporated into the backbone polymers to provide for degradation low molecular weight hydrophilic compounds upon lowering pH. All demonstrated pH-dependent profile with very significant increase in hydrolysis rate as pH was lowered from 7.4 value 5.0 commonly found lysosomes. half-life varied 0.03 81.5 days at 6.0 161 7.4, depending structure components used prepare each acid-degradable polymers. This data suggests that these new analogous structures may prove useful field polymer therapeutics drug delivery.