Heterogeneity in lobar and near-acini deposition of inhaled aerosol in the mouse lung

摘要: Abstract Laboratory animals are often used to derive health risk from environmental exposure or assess the therapeutic effect of a drug delivered by inhaled therapy. Knowledge in-situ distribution deposited particles on airway and alveolar surfaces is essential in any assessment these effects. A unique database including both high-resolution lung anatomy deposition data four strains laboratory mice have been recently made publicly available research community ( https://doi.org/10.25820/9arg-9w56 ). Using data, we investigated particle size at lobar near-acini level. Analysis was performed total 33 where 3, 16 14 were exposed 0.5 μm, 1 μm 2 μm particles, respectively. Ratio normalized volume calculated for each lobe D V l o b e At level, skew standard deviation frequency calculated. Significant above 1 found DV ratio cranial C r n i M d , u c s y all significantly f t (p