Thioridazine affects transcription of genes involved in cell wall biosynthesis in methicillin-resistant Staphylococcus aureus.
作者： Mette Bonde , Dorte H. Højland , Hans Jørn Kolmos , Birgitte H. Kallipolitis , Janne K. Klitgaard
DOI: 10.1111/J.1574-6968.2011.02255.X
关键词:
摘要: The antipsychotic drug thioridazine is a candidate for an alternative treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) in combination with the β-lactam antibiotic oxacillin. has been shown to have capability resensitize MRSA We previously that expression some resistance genes abolished after and To further understand mechanism underlying reversal resistance, we tested involved cell wall biosynthesis response observed oxacillin-induced belonging VraSR regulon reduced addition thioridazine. exclusion such key factors will most likely lead weakened affect ability bacteria sustain oxacillin treatment. Furthermore, found itself reduces level selected virulence toxin are not induced In present study, find indications relies on decreased specific biosynthesis.
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