Does the presence of emphysema increase the risk of radiation pneumonitis in lung cancer patients

摘要: Introduction Radiotherapy (rt) plays an important role in the treatment of lung cancer. One most common comorbidities patients with cancer is pulmonary emphysema. The literature offers conflicting data about whether emphysema increases occurrence and severity radiation pneumonitis (rp). As a result, high doses rt (with curative intent) should be avoided still unclear. Objective We measured documented incidence rp without who received treatment. Methods This retrospective cohort study considered clinical database Peter Brojde Lung Cancer Centre. Data from has been used previously for research studies, including recent publication grading, based on percentage occupied by computed tomography (ct) imaging. Results Using published methods, chest ct imaging 498 was scored presence analysis 114 at least 30 Gy radiation. Of those patients, 64 (56%) had emphysema, approximately 23% having severe or very disease. 34.4% ( n = 22) 32.0% no 16, p 0.48). No difference evident between various grades 0.96). Similarly, two protocols—that is, definitive 17 (37%) combined chemotherapy–rt 21 (31%, 0.5). Conclusions In our cohort, not associated increased risk rp. That finding suggests that offered when clinically indicated. However, further prospective studies will needed confirmation.