Hen Egg White Lysozyme Catalyzed Efficient Synthesis of 3-Indolyl-3-hydroxy Oxindole in Aqueous Ethanol
作者： Kiran S. Dalal , Yogesh B. Wagh , Yogesh A. Tayade , Dipak S. Dalal , Bhushan L. Chaudhari
DOI: 10.1007/S10562-018-2551-9
关键词:
摘要: A green synthesis of 3-indolyl-3-hydroxy oxindoles was reported using hen egg white lysozyme (HEWL) in an aqueous ethanol. The HEWL promotes this reaction efficiently from various isatins and indoles under mild conditions with yields up to 98% bearing good adaptability varied substrates the reaction. This conversion has provided a new strategy synthesize oxindole derivatives employing biocatalytic promiscuity less explored lysozyme. Based on experimental studies, plausible mechanism is proposed.
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