Friedel–Crafts alkylation of indoles in deep eutectic solvent

作者: Atul Kumar , Ratnakar Dutt Shukla , Dhiraj Yadav , Lalit Prakash Gupta

DOI: 10.1039/C5RA08038J

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摘要: The application of Deep Eutectic Solvent (DES) as a solvent and working catalyst for Friedel–Crafts alkylation indoles with isatin well homocyclic carbonyl compounds has been developed. salient features the present protocol are practical simplicity, excellent yields, product selectivity reusability reaction media.

参考文章(47)
Qinghua Zhang, Karine De Oliveira Vigier, Sébastien Royer, François Jérôme, Deep eutectic solvents: syntheses, properties and applications Chemical Society Reviews. ,vol. 41, pp. 7108- 7146 ,(2012) , 10.1039/C2CS35178A
Amy B. Dounay, Larry E. Overman, The asymmetric intramolecular Heck reaction in natural product total synthesis. Chemical Reviews. ,vol. 103, pp. 2945- 2964 ,(2003) , 10.1021/CR020039H
Feng Zhou, Yun-Lin Liu, Jian Zhou, Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C‐3 Position Advanced Synthesis & Catalysis. ,vol. 352, pp. 1381- 1407 ,(2010) , 10.1002/ADSC.201000161
Atul Kumar, Mukesh Kumar, Maneesh Kumar Gupta, Catalyst-free hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes in water Green Chemistry. ,vol. 14, pp. 2677- 2681 ,(2012) , 10.1039/C2GC35741K
Marco Bandini, Astrid Eichholzer, Catalytic Functionalization of Indoles in a New Dimension Angewandte Chemie. ,vol. 48, pp. 9608- 9644 ,(2009) , 10.1002/ANIE.200901843
Marija Petkovic, Kenneth R. Seddon, Luís Paulo N. Rebelo, Cristina Silva Pereira, Ionic Liquids: A Pathway to Environmental Acceptability Chemical Society Reviews. ,vol. 40, pp. 1383- 1403 ,(2011) , 10.1039/C004968A
RICHARD J SUNDBERG, Five-Membered Ring Systems: Pyrroles and Benzo Derivatives ChemInform. ,vol. 1, pp. 110- 128 ,(1989) , 10.1016/B978-0-08-037045-3.50012-9
Jan Bergman, Nils Eklund, Synthesis and studies of tris-indolobenzenes and related compounds Tetrahedron. ,vol. 36, pp. 1445- 1450 ,(1980) , 10.1016/0040-4020(80)85060-5
V. Pavan Kumar, V. Prakash Reddy, R. Sridhar, B. Srinivas, M. Narender, K. Rama Rao, Supramolecular Synthesis of 3-Indolyl-3-hydroxy Oxindoles under Neutral Conditions in Water The Journal of Organic Chemistry. ,vol. 73, pp. 1646- 1648 ,(2008) , 10.1021/JO702496S
Christiane Marti, Erick M. Carreira, Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids European Journal of Organic Chemistry. ,vol. 2003, pp. 2209- 2219 ,(2003) , 10.1002/EJOC.200300050