Solvent-Controlled Friedel–Crafts Reaction for the Synthesis of 3-Indolyl-3-hydroxy Oxindoles and 3, 3-Diindolyl Oxindoles Catalyzed by Dabco-Base Ionic Liquids
作者： Jun Tong , Yu-Wei Li , Da-Zhen Xu
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摘要: Solvent-controlled Friedel–Crafts reaction of indoles with various isatins catalyzed by 1,4-diazobicyclo[2.2.2]octane(DABCO)-base ionic liquids for a general route toward synthesis 3-indolyl-3-hydroxy oxindoles and 3, 3-diindolyl has been successful developed. When the was performed in THF, only monoindolylation products were obtained good to excellent yields (70–96%). While water employed as solvent, sole (85–98%). Plausible mechanisms proposed according experimental results.
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