Perspectives in PML: a unifying framework for PML function

摘要: The promyeloctyic leukemia protein (PML) has established activities as a potent repressor of proliferation, and oncogenic transformation, promoter apoptosis, an inducer senescence, may act inhibitor angiogenesis in mammalian systems. Loss PML or its nuclear bodies is associated with many human disease states. At the molecular level, protein, bodies, play roles diverse events ranging from mRNA export to DNA repair. expression impacts on Akt survival signaling, p53/Mdm2 activity, cell cycle progression, name few. However, there no discrete set that underlie biochemical physiological effects. In this review, we postulate possible model function could provide unifying underpinning for disparate activities. particular, explore how ability coordinately combinatorially regulate gene post-transcriptionally, enables have such broad effects cellular physiology.