Puzzled by PML

摘要: Promyelocytic leukemia (PML) protein nuclear bodies are one of many structures found in the nucleus higher eukaryotes. There about 10 to 30 these spherical per nucleus, ranging size from ∼0.2 1 µm diameter. PML (also known as oncogenic domains, Kremer bodies, or dot 10s) currently defined by presence ( ). They were first identified 1960s, but their relationship with was only described 20 years ago 2 , 3 inhibits cell cycle progression, promotes death, suppresses some types transformation and senescence, acts stem renewal, plays a role defense against viruses – 5 Although effects well described, underlying molecular mechanisms not. On page 1247 this issue, Giorgi et al. 6 ) propose that controls calcium signaling at endoplasmic reticulum (ER), potentially increasing its functional diversity.