Third‐Order Neuronal Responses Contribute to Shaping the Negative Electroretinogram in Sodium Iodate–Treated Rats
作者： Michiko Tanaka , Shigeki Machida , Kouji Ohtaka , Yutaka Tazawa , Junfuku Nitta
DOI: 10.1080/02713680590959330
关键词:
摘要: Purpose: To determine possible mechanisms that shape the negative electroretinograms (ERGs) in rats with photoreceptor degeneration induced by destruction of retinal pigment epithelium. Methods: Sprague-Dawley (n = 48) were injected intravenously 60 mg/kg sodium iodate (NaIO3). Full-field ERGs elicited different stimulus intensities a maximum luminance 1.23 log cd-s/m2 and recorded at 6 hr on days 7, 14, 28 after NaIO3 injections. DL-2-amino-4-phosphonobutyric acid (APB, 1 mM) or N-methyl-L-aspartic (NMDA, 5 was into vitreous cavity to isolate (PIII), second-order, third-order neuronal responses. After recording ERGs, animals sacrificed for histological analysis. Results: Negative under scotopic conditions day 7 injection. An intravitreal injection NMDA eliminated most a-wave, resulting abolition ERG. On 14 28, a-wave amplitudes w...
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