Treatment of Bacterial Osteomyelitis and Staphylococcus aureus Endocarditis and Single-Dose Therapy for Uncomplicated Neisseria gonorrhoeae Infections: An Overview

摘要: Cefonicid is a new second-generation cephalosporin that has broad-spectrum antibacterial activity, achieves high peak serum concentrations, and long half-life. The concentration half-life of cefonicid make it feasible to administer the drug once daily either intravenously or intramuscularly. For treatment bacterial osteomyelitis, specific agent administered for four eight weeks. Ideally, optimal antibiotic should have good activity against organisms commonly implicated in bone infections, be easy administer, stable inflammatory conditions, achieve concentrations bone, minimal toxicity. Staphylococcus aureus endocarditis, same criterion toxicity met used; addition, excellent antistaphylococcal vivo vitro, p-lactamase, exhibit bactericidal at trough levels. In uncomplicated Neisseria gonorrhoeae ideal one could single dose small volume would not painful on intramuscular injection. nontoxic; N. p-lactamase; reliably able eradicate urethral, endocervical, rectal, pharyngeal infections. may fulfill some these criteria.