Incidence, therapy, and consequences of lymphocele after sirolimus-cyclosporine-prednisone immunosuppression in renal transplant recipients

摘要: BACKGROUND In a retrospective study we sought to dissect the factors associated with an increased occurrence of clinically significant perinephric fluid collections and lymphoceles among sirolimus-treated renal transplant recipients. METHODS We compared incidence, predisposing factors, consequences these patients treated sirolimus-cyclosporine (CsA)-prednisone (Pred) (n=354, group I) versus CsA-Pred or without azathioprine (n=136, II). RESULTS More I (135/354; 38.1%) displayed (denoted as III) then II (24/136; 17.6%) IV) (P <0.001). both subgroups serum creatinine levels were elevated at time diagnosis from nadir 2.04+/-1.61 4.09+/-2.95 mg/dL (group 2.53+/-2.34 4.36+/-2.90 IV). A significantly greater number required treatment for (56/354; 15.8%) recipients (6/136; 4.4%; P<0.001). Single repeated percutaneous drainage procedures successfully 35 all 6 IV =0.033). No in 21 underwent surgical higher rate histologic grade acute rejection episodes, particularly proximate onset lymphocele, occurred patients, namely 54.2% (13/24) 21.4% (29/135) III CONCLUSIONS Addition sirolimus regimen resulted incidence requirement more aggressive lymphoceles.